Microneedle Characterization Using a Double-Layer Skin Simulant

Enhancement of optical skin clearing efficacy using a microneedle roller.

Light scattering in biological tissues can be reduced by using optical clearing agents. Various physical methods in conjunction with agents have been studied to enhance the optical clearing efficacy of skin for diagnostic and therapeutic applications. In this study, we propose a new physical method to enhance the optical clearing potential of topically applied glycerol. A microneedle roller is ...

Optical effects of pigmentation on temperature rise in a two-layer skin simulant system during irradiation.

Macromolecular delivery into skin using a hollow microneedle.

The objective of the present study was to obtain information to develop an effective delivery device regarding a sophisticated hollow microneedle array-patch system. Thus, the potential of hollow microneedles was investigated for enhancing the transdermal delivery of hydrophilic large molecular compounds, and the effect of variable parameters on drug release behavior was determined from skin. F...

TOPOLOGY OPTIMIZATION OF DOUBLE LAYER GRIDS FOR EARTHQUAKE LOADS USING A TWO-STAGE ESO-ACO METHOD

A two-stage optimization method is presented by employing the evolutionary structural optimization (ESO) and ant colony optimization (ACO), which is called ESO-ACO method. To implement ESO-ACO, size optimization is performed using ESO, first. Then, the outcomes of ESO are employed to enhance ACO. In optimization process, the weight of double layer grid is minimized under various constraints whi...

Measuring knife stab penetration into skin simulant using a novel biaxial tension device.

This paper describes the development and use of a biaxial measurement device to analyse the mechanics of knife stabbings. In medicolegal situations it is typical to describe the consequences of a stabbing incident in relative terms that are qualitative and descriptive without being numerically quantitative. Here, the mechanical variables involved in the possible range of knife-tissue penetratio...